Influence of ghrelin on energy balance and endocrine physiology.

نویسندگان

  • Hanna Komarowska
  • Magdalena Jaskula
  • Adam Stangierski
  • Ryszard Wasko
  • Jerzy Sowinski
  • Marek Ruchala
چکیده

Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor. It is mainly secreted by stomach cells but has also been shown to be present in the hypothalamus, pituitary, gonads and many other organs. Ghrelin is a regulator of energy homeostasis and GH secretion. Many studies have been done examining the influence of ghrelin on different organs. Ghrelin may play an important role in pathophysiology of some endocrine diseases. The relationship between ghrelin and pituitary, gonads and thyroid function appears to be specially interesting.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin.

Ghrelin is a peptide predominantly produced by the stomach. Ghrelin displays strong GH-releasing activity. This activity is mediated by the activation of the so-called GH secretagogue receptor type 1a. This receptor had been shown to be specific for a family of synthetic, peptidyl and nonpeptidyl GH secretagogues. Apart from a potent GH-releasing action, ghrelin has other activities including s...

متن کامل

Ghrelin: a novel player in the gut-brain regulation of growth hormone and energy balance.

Ghrelin is a newly discovered peptide hormone produced by the stomach that displays potent growth hormone-releasing activity and a stimulatory effect on food intake and digestive function while reducing energy expenditure. The isolation of ghrelin has led to new insights into how this gastric hormone links the endocrine control of nutritional homeostasis with growth hormone secretion and gastro...

متن کامل

The Effect of Intravascular Injection of Ghrelin on the Mean Plasma Concentrations of Insulin and ACTH in Immature Camels Fed with Diets Containing Different Levels of their Energy Requirements

Introduction: Ghrelin is a peptide hormone secreted from the stomach with both endocrine and paracrine effects. Ghrelin and its mRNA as well as growth hormone (GH) secretagogue receptor mRNAs are expressed in the pancreas and islet cells and regulate insulin release. Also the immounoreactivity of ghrelin is proved to be high in the hypothalamus and parts of the brain responsible for the re...

متن کامل

Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin.

BACKGROUND/AIMS The gastric peptide ghrelin, an endogenous ligand for growth-hormone secretagogue receptor, has two major molecular forms: acylated ghrelin and desacyl ghrelin. Acylated ghrelin induces a positive energy balance, while desacyl ghrelin has been reported to be devoid of any endocrine activities. The authors examined the effects of desacyl ghrelin on energy balance. METHODS The a...

متن کامل

Effects of CP 55,940--agonist of CB1 cannabinoid receptors on ghrelin and somatostatin producing cells in the rat pancreas.

Cannabinoids participate in the modulation of numerous functions in the human organism, increasing the sense of hunger, affecting carbohydrate and lipid metabolism, and controlling systemic energy balance mechanisms. Moreover, they influence the endocrine system functions, acting via two types of receptors, CB1 and CB2. The aim of the present study was to examine the number, distribution and ac...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Neuro endocrinology letters

دوره 33 8  شماره 

صفحات  -

تاریخ انتشار 2012